Novel technologies for oral delivery of poorly soluble drugs

摘要

ABSTRACT The preferred route of oral administration is limited to those drug molecules that are permeable across the gastric mucosa and are at least sparingly soluble. A large majority of the new chemical entities and many existing drug molecules are poorly soluble, thereby limiting their potential uses and increasing the difficulty of formulating bioavailable drug products. There are numerous methods that may facilitate solubility to further enhance performance of poorly soluble drugs for oral.