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Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug

机译：自行纳米乳化的药物输送系统的开发，以提高非水溶性药物非诺贝特的溶解度和口服生物利用度

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BackgroundSelf-nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this study was to investigate the factor that can influence the design of successful lipid formulation classification system (LFCS) Type III SNEDDS formulation and improve the oral bioavailability (BA) of fenofibrate.

机译：背景技术自纳米乳化药物递送系统（SNEDDS）已作为水溶性差的药物的纳米载体成为一种流行的配方选择。这项研究的目的是研究可影响成功的脂质制剂分类系统（LFCS）III型SNEDDS制剂设计并提高非诺贝特口服生物利用度（BA）的因素。

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期刊名称 International Journal of Nanomedicine
作者
Kazi Mohsin; Rayan Alamri; Ajaz Ahmad; Mohammad Raish; Fars K Alanazi; Muhammad Delwar Hussain;
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作者单位

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年(卷),期 1988(11),
年度 1988
页码 2829–2838
总页数 10
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
lipid-based formulation, self-nanoemulsifying drug delivery systems, fenofibrate, solubility improvement, oral bioavailability;

机译：基于脂质的配方;自纳米乳化的药物输送系统;非诺贝特;溶解度改善;口服生物利用度;

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专利

1. Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug [J] . Kazi Mohsin, Rayan Alamri, Ajaz Ahmad, International Journal of Nanomedicine . 2016,第Supplementa1期

机译：自行纳米乳化的药物输送系统的开发，以提高非水溶性药物非诺贝特的溶解度和口服生物利用度
2. Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics [J] . Seo Youn Gee, Kim Dong Wuk, Yousaf Abid Mehmood, Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2015,第1a8期

机译：固体自纳米乳化药物递送系统（SNEDDS），用于提高水溶性较差的他克莫司的口服生物利用度：物理化学表征和药代动力学
3. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin [J] . Jie Lai, Jianming Chen, Yi Lu, AAPS PharmSciTech . 2009,第3期

机译：甘油单油酸酯/泊洛沙姆407立方纳米颗粒作为口服药物输送系统：I.水溶性较差的药物辛伐他汀的体外评估和口服生物利用度的提高
4. Novel Self-nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery ofEssential Oil: Formulation and Bioavailability Study [C] . Y. Zheng, Y Zhao, C.G. Wang, . 2009

机译：口服精油的新型自乳化药物输送系统（SNEDDS）：制剂和生物利用度研究
5. Development of a self-nanoemulsifying drug delivery system for oral delivery of beta-lactamase. [D] . Venkata Ramana Rao, Sripriya. 2008

机译：开发了用于口服β-内酰胺酶的自纳米乳化药物递送系统。
6. Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs [O] . Nicky Thomas, René Holm, Mats Garmer, 2013

机译：超饱和自纳米乳化药物递送系统（Super-SNEDDS）增强了狗中水溶性较差的药物辛伐他汀的生物利用度
7. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin [O] . Lai, Jie, Chen, Jianming, Lu, Yi, 2009

机译：甘油单油酸酯/泊洛沙姆407立方纳米颗粒作为口服药物输送系统：I.水溶性较差的药物辛伐他汀的体外评估和口服生物利用度的提高

Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug

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