Is KCNQ Channel a Mediator of Urinary Bladder Disorders in Multiple Sclerosis ?

摘要

ABSTRACT The KCNQ encoded channels in such pacemaker cells as well as smooth muscles regulate the excitability and membrane physiology. ICC like cells in the ureter are distributed throughout the ureter with higher distribution in the upper ureter i.e pyeloureteric junction. These cells in the absence of neural input can still maintain peristalsis for propulsion of urine from the kidney to ureter. Ion channels encoded by the KCNQ gene family (Kv7.1.