Development and In Vitro Evaluation of Mucoadhesive Buccal Tablets of Tizanidine Hydrochloride Using Natural Polymer Locust Gum

摘要

ABSTRACT In the present work mucoadhesive buccal tablets of Tizanidine hydrochloride (TZD HCl) were prepared by using locust gum and in combination of locust gum with sodium alginate as mucoadhesive polymers. Seven formulations were developed with varying concentrations of polymers. The prepared tablets were evaluated for the weight variation, thickness, hardness, friability, surface pH, swelling index, mucoadhesive strength and in vitro drug release. All the formulations displayed zero order r.