Protective Effects of Aqueous Extract of Sphaeranthus indicus L on Paracetamol Induced Hepatic Damage in Rats

摘要

ABSTRACT Aqueous extract of root of Sphaeranthus indicus L. was evaluated for hepatpprotective activity in rats. The plant extract 200 & 300 mg/kg body weight showed a remarkable hepatoprotective activity against acetaminophen induced hepatotoxicity as judged from the serum marker enzymes levels in liver tissues. Paracetamol overdose caused significant (p<0.001) increase in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), acid phosphatase, -Glutamy.