Design and Evaluation of Rectal Suppositories of Antihypertensive Drug

摘要

ABSTRACT In the present study an attempt has been made to design and evaluate rectal suppositories of atenolol an antihypertensive drug. suppositories were formulated utilizing different hydrophilic and hydrophobic polymeric bases like gelatin, PEG-400 and hydrogenated vegetable oil in combination with propylene glycol as plasticizer and beeswax as hardening agent by fusion method. The statistical evaluation of in-vitro release data depicted that the mechanism of drug release from all the formu.