Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: Focus on Parkinson's disease

摘要

Inthisreviewwediscusstheadvantagesandunresolvedissuesofcellreprogrammingandneuronaldifferentiation.WereviewedevidenceusingiPSCs‐derivedneuronsfromneurologicalpatients.FocusingondataobtainedfromParkinson'sdisease(PD)patients,weshowthatiPSC‐derivedneuronspossessmorphologicalandfunctionalcharacteristicsofthisdiseaseandbuildacasefortheuseofthistechnologytostudyPDandotherneuropathologieswhilediseaseisinprogress.Thesedatashowtheenormousimpactthatthisnewtechnologystartstohaveondifferentpurposessuchasthestudyanddesignoffuturetherapiesofneurologicaldisease,especiallyPD...