The activity of cAMP‐phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A‐dependent phosphorylation within its unique N‐terminus

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The activity of cAMP‐phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A‐dependent phosphorylation within its unique N‐terminus

机译：cAMP‐磷酸二酯酶4D7（PDE4D7）的活性受其独特N端蛋白激酶A依赖性磷酸化的调节

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ThecyclicAMPphosphodiesterasestype4(PDE4s)areexpressedinacellspecificmanner,withintracellulartargetingdirectedbyuniqueN‐terminalanchordomains.AlllongformPDE4sarephosphorylatedandactivatedbyPKAphosphorylationwithintheirupstreamconservedregion1(UCR1).Here,weidentifyandcharacteriseanovelPKAsite(serine42)withintheN‐terminalregionofPDE4D7,anisoformwhoseactivityisknowntobeimportantinprostatecancerprogressionandischemicstroke.IncontrasttotheUCR1site,PKAphosphorylationofthePDE4D7N‐terminusappearstooccurconstitutivelyandinhibitsPDE4activitytoallowcAMPsignallingunderbasalconditions...

机译：ThecyclicAMPphosphodiesterasestype4（PDE4s）areexpressedinacellspecificmanner，withintracellulartargetingdirectedbyuniqueN-terminalanchordomains.AlllongformPDE4sarephosphorylatedandactivatedbyPKAphosphorylationwithintheirupstreamconservedregion1（UCR1）。在这里，weidentifyandcharacteriseanovelPKAsite（serine42）withintheN-terminalregionofPDE4D7，anisoformwhoseactivityisknowntobeimportantinprostatecancerprogressionandischemicstroke.IncontrasttotheUCR1site，PKAphosphorylationofthePDE4D7N-terminusappearstooccurconstitutivelyandinhibitsPDE4activitytoallowcAMPsignallingunderbasalconditions ...

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《FEBS Letters》 |2015年第6期|共6页
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入库时间 2022-08-18 19:15:09

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1. The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus [J] . Byrne Ashleigh M., Elliott Christina, Hoffmann Ralf, FEBS letters. . 2015,第6期

机译：cAMP-磷酸二酯酶4D7（PDE4D7）的活性受其独特N端蛋白激酶A依赖性磷酸化的调节
2. Modulation of the interaction between chemotactic cAMP‐receptor and N‐protein by cAMP‐dependent kinase in Dictyostelium discoideum membranes [J] . Ludeacute, rus M.E.E., van der Meer R.F., FEBS Letters . 1986,第2期

机译：盘基网柄菌膜中cAMP依赖性激酶对趋化性cAMP受体与N蛋白之间相互作用的调节
3. Phosphorylation of neurofibromin by cAMP‐dependent protein kinase is regulated via a cellular association of N G,N G‐dimethylarginine dimethylaminohydrolase [J] . Araki Norie, Feng Liping, Kimoto Masumi, FEBS Letters . 2001,第1a2期

机译：cAMP依赖性蛋白激酶对神经纤维蛋白的磷酸化通过N G，N G-二甲基精氨酸二甲基氨基水解酶的细胞结合来调节
4. Phosphorylation regulates the phosphodiesterase activity of GDPD5, an enzyme that breaks down the osmoprotective organic osmolyte glycerophosphocholine [C] . Supachai Topanurak, Joan D. Ferraris, Jinxi Li, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：磷酸化调节GDPD5的磷酸二酯酶活性，一种破坏渗透渗透有机渗透甘油磷机的酶
5. The regulation of cardiac L-type voltage-dependent calcium channel function by cAMP-dependent protein kinase mediated phosphorylation: Biochemical studies of heterologously expressed and native channels. [D] . Puri, Tipu Sultan. 1998

机译：cAMP依赖性蛋白激酶介导的磷酸化对心脏L型电压依赖性钙通道功能的调节：异源表达和天然通道的生化研究。
6. The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus [O] . Ashleigh M. Byrne, Christina Elliott, Ralf Hoffmann, -1

机译：cAMP磷酸二酯酶4D7（PDE4D7）的活性受其独特N端蛋白激酶A依赖性磷酸化的调节
7. The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus [O] . Byrne Ashleigh M., Elliott Christina, Hoffmann Ralf, 2015

机译：cAMP磷酸二酯酶4D7（PDE4D7）的活性受其独特N端蛋白激酶A依赖性磷酸化的调节

The activity of cAMP‐phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A‐dependent phosphorylation within its unique N‐terminus

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