Long non‐coding RNA HOTAIR modulates c‐KIT expression through sponging miR‐193a in acute myeloid leukemia

摘要

HOTAIRissignificantlyoverexpressedinvariouscancersandfacilitatestumorinvasionandmetastasis.However,whetherHOTAIRplaysoncogenicrolesinacutemyeloidleukemia(AML)isstillunknown.Here,wereportthatHOTAIRexpressionwasobviouslyincreasedinleukemiccelllinesandprimaryAMLblasts.Clinically,AMLpatientswithhigherHOTAIRpredictedworseclinicaloutcomecomparedwiththosewithlowerHOTAIR.Importantly,HOTAIRknockdownbysmallhairpinRNAinhibitedcellgrowth,inducedapoptosis,anddecreasednumberofcolonyformation.Finally,HOTAIRmodulatedc‐KITexpressionbycompetitivelybindingmiR‐193a.Collectively,ourdatasuggestthatHOTAIRplaysanimportantoncogenicroleinAMLandmightserveasamarkerforAMLprognosisandapotentialtargetfortherapeuticintervention...