Effect of amino acid distribution of amphipathic helical peptide derived from human apolipoprotein A‐I on membrane curvature sensing

摘要

Amphipathichelix,whichsensesmembranecurvature,isofgrowinginterest.HereweexploretheeffectofaminoaciddistributionofamphipathichelicalpeptidederivedfromtheC‐terminalregion(residues220–241)ofhumanapolipoprotein(apo)A‐Ionmembranecurvaturesensing.Thispeptidepreferredacurvedmembraneinamannersimilartofull‐lengthapoA‐I,althoughitsmodelpeptidedidnotsensemembranecurvature.Substitutionofseveralresiduesbothonthepolarandnon‐polarfacesoftheamphipathichelixhadnosignificanteffectonsensing,suggestiveoftheelaboratemoleculararchitectureintheC‐terminalhelicalregionofapoA‐Itoexertlipideffluxfunction...