Subsets of ATP‐sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression

摘要

Gapjunctionalintercellularcommunication(GJIC)regulatescellularhomeostasisbypropagatingsignalingmolecules,exchangingcellularmetabolites,andcouplingelectricalsignals.Incancer,cellsexhibitalteredratesofGJICwhichmayplayaroleinneoplasticprogression.KATPchannelshelpmaintainmembranepolarityandlinkagesbetweenKATPchannelactivityandratesofGJIChavebeenestablished.Themechanisticrelationshiphasnotbeenfullyelucidated.WereporttheeffectsoftreatmentwithmultipleKATPantagonistcompoundsonGJICinmetastaticcelllinesdemonstratinganincreaseincommunicationratesfollowingtreatmentwithcompoundspossessingspecificitiestowardstheSUR2subunitofKATP.TheseeffectsremainedconsistentusingcelllineswithdifferentexpressionlevelsofSUR1andSUR2,suggestingpossibleofftargeteffectsonGJICbythesecompounds...