Are biological sensors modulated by their structural scaffolds? The role of the structural muscle proteins α‐actinin‐2 and α‐actinin‐3 as modulators of biological sensors

摘要

Biologicalsensorsandtheirabilitytodetectandrespondtochangeinthecellularenvironmentcanbemodulatedbyproteinscaffoldsactingwithintheirinteractionnetwork.Theskeletalmuscleα‐actininshavebeenconsideredasprimarilystructuralscaffoldproteins.However,deficiencyofα‐actinin‐3duetoacommonnullpolymorphismresultsinpredominantlymetabolicchangesinskeletalmusclefunction.Inthisreview,weexploretherangeofphenotypesassociatedwithα‐actinin‐3deficiency,anddrawsupportingevidencefromknowninteractionpartnersforitsroleasascaffoldwhichactstomodulatebiologicalsensorsthatresultinchangesinmusclemetabolismandstructure...