Modeling membrane shaping by proteins: Focus on EHD2 and N‐BAR domains

摘要

Cellularmembranesarehighlydynamic,undergoingbothpersistentanddynamicshapechangesdrivenbyspecializedproteins.Theobservedmembraneshapingcanbesimpledeformationsofexistingshapesormembraneremodelinginvolvingfissionorfusion.Herewedescribeseveralmechanisticprinciplesbywhichmembraneshapingproteinsact.WeespeciallyconsidermodelsformembranebendingandfissionbyEHD2proteinsandmembranebendingbyN‐BARdomains.Therearemajorchallengesaheadtounderstandthegeneralprinciplesbywhichdiversemembranebendingproteinsactandtounderstandhowsomeproteinsappeartospanmultiplemodesofactionfromdrivingcurvaturetoinducingmembraneremodeling...