Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver

摘要

>The effect of vitamin B₆ deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B₆-deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for β-actin and glyceraldehyde-3-phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in vitamin deficiency. These observations suggest that vitamin B₆ influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.