Evidence of an α2‐macroglobulin‐like molecule in plasma of Salamandra salamandra Structural and functional similarity with human α2‐macroglobulin

摘要

>A high-M_r (M _r 750 000) α₁ -macroglobulin, obtained from Salamandra salamandra, is described. Salamander α₁-macroglobulin is composed of two monomers of equal M _r, which are composed of two polypeptide chains, each of M _r 180 000, linked by disulfide bonds. The molecular parameters of this protein, its binding to trypsin and inactivation by methylamine suggest that salamander α₁-macroglobulin is closely related to human α₂-macroglobulin and to other related proteins described in the animal kingdom.