Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration

摘要

Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration.BackgroundLymphocytic infiltration is obvious throughout early and late stages of chronic allograft nephropathy. Early infiltrating lymphocytes are involved in initial insults to kidney allografts, but the contribution of late infiltration to long-term allograft attrition is still controversial. Early application of FTY720 reduced the number of graft infiltrating lymphocytes, and inhibited acute rejection. The present study investigated the potential of FTY720 to reduce the number of infiltrating lymphocytes even at a late stage, and, thus, slow the pace of chronic allograft nephropathy.