Endothelial cell chimerism occurs more often and earlier in female than in male recipients of kidney transplants

摘要

Endothelial cell chimerism occurs more often and earlier in female than in male recipients of kidney transplants.BackgroundEndothelial chimerism occurs in renal transplants, but factors involved in its development and its impact on outcome, are unknown. Most studies on chimerism are restricted to gender-mismatched combinations of female donor organs into male recipients. By using blood group antigen mismatches to detect chimeric cells, we circumvented this restriction. We determined which factors predispose for the development of endothelial chimerism, and how it influences graft survival.