Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury

摘要

Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury.BackgroundCaspase-6 is an important member of the executioner caspases in the caspase family of cell death proteases. The executioner caspases are the major active caspases detected in apoptotic cells and are generally considered to mediate the execution of apoptosis by cleaving and inactivating intracellular proteins. However, the complete characterization of mRNA and protein of caspase-6 in rat and its expression in normal kidney and in disease state has not been previously elucidated.