Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases

ANNA SOLINI; CARLA IACOBINI; CARLO RICCI; PAOLA CHIOZZI; LORENA AMADIO; FLAVIA PRICCI; UMBERTO DI MARIO; FRANCESCO DI VIRGILIO; GIUSEPPE PUGLIESE

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Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases

机译：肾小球系膜细胞外基质产生的嘌呤能调节：在糖尿病和其他肾小球疾病中的作用

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Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases.BackgroundExtracellular adenosine triphosphate (ATP) (eATP) mediates several biologic activities via purinergic P2 receptors (P2Rs). This study aimed at (1) evaluating the role of the purinergic system in modulating mesangial extracellular matrix (ECM) and transforming growth factor- (TGF-) production and (2) its contribution to diabetes-induced mesangial ECM accumulation.

机译：肾小球系膜细胞外基质产生的嘌呤能调节：在糖尿病和其他肾小球疾病中的作用背景胞外三磷酸腺苷（ATP）通过嘌呤能P2受体（P2Rs）介导多种生物学活性。这项研究旨在（1）评估嘌呤能系统在调节肾小球系膜细胞外基质（ECM）和转化生长因子（TGF-）产生中的作用，以及（2）它对糖尿病诱导的肾小球系膜ECM积累的作用。

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《Kidney international.》 |2005年第3期|共11页
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ANNA SOLINI; CARLA IACOBINI; CARLO RICCI; PAOLA CHIOZZI; LORENA AMADIO; FLAVIA PRICCI; UMBERTO DI MARIO; FRANCESCO DI VIRGILIO; GIUSEPPE PUGLIESE;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases [J] . ANNA SOLINI, CARLA IACOBINI, CARLO RICCI, Kidney international. . 2005,第3期

机译：肾小球系膜细胞外基质产生的嘌呤能调节：在糖尿病和其他肾小球疾病中的作用
2. Differential regulation of intracellular redox state by extracellular matrix proteins in glomerular mesangial cells: potential role in diabetic nephropathy [J] . Nakajima Toshiki, Hasegawa Goji, Kamiuchi Kenji, Redox Report . 2006,第5期

机译：肾小球系膜细胞中细胞外基质蛋白对细胞内氧化还原状态的差异调节：在糖尿病肾病中的潜在作用
3. Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/beta-TrcP/Nrf2 pathway [J] . Qiao Simiao, Liu Rui, Lv Changjun, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2019,第期

机译：Bergenin通过MTOR /β-TRCP / NRF2途径抑制氧化应激，在肾小球乳腺细胞中产生细胞外基质的产生，并在小鼠中改善糖尿病肾病。
4. A MODEL OF GLOMERULAR MESANGIAL TRANSPORT IN HEALTH AND DISEASE [C] . Sarah Hunt, Yoav Segal, Kevin D. Dorfman, ASME bioengineering conference . 2014

机译：健康与疾病中的肾小球系膜运输模型
5. Role of endothelin-1 (ET-1) in glomerular inflammation and glomerular permeability in normal and diabetic kidneys. [D] . Saleh, Mohamed Ahmed. 2010

机译：内皮素-1（ET-1）在正常和糖尿病肾小球炎症和肾小球通透性中的作用。
6. Repression of microRNA‐382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy [O] . Shan Wang, Xin Wen, Xin‐Rui Han, 2018

机译：抑制microRNA-382抑制糖尿病肾病小鼠中肾小球系膜细胞增殖和通过FoxO1的细胞外基质积累
7. Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases [O] . SOLINI A, IACOBINI C, RICCI C, 2005

机译：肾小球系膜细胞外基质产生的嘌呤能调节：在糖尿病和其他肾小球疾病中的作用

Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases

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