Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-|[kgr]|B dependent

摘要

Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-B dependent.BackgroundEndotoxin is an important factor in the development of acute renal failure related to infection and in acceleration of chronic nephritis. Lipopolysaccharide (LPS; the major component of endotoxin) is one of the most potent triggers for renal cells to produce monocyte chemoattractant protein-1 (MCP-1), a key cytokine involved in immune cell recruitment into the renal interstitium in acute and chronic renal diseases. Knowledge about the transcriptional regulation of MCP-1 in renal tubular epithelial cells in response to LPS is incomplete.