New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production

摘要

Three new benzenoid derivatives, lawsoinermone ( 1 ), inermidioic acid ( 2 ), and inermic acid ( 3 ) have been isolated from the aerial part of Lawsonia inermis , together with 11 known compounds ( 4 – 14 ). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1 , 4 – 6 , 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC 50 values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively.