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New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production

机译:具有抑制NO生成活性的无定律的新Benzenoid衍生物和其他成分

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Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC50 values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively. View Full-Text
机译:从无棉劳森菌的地上部分中分离出了三种新的苯甲酮衍生物,即法诺尔内酮(1),茚三酮酸(2)和Inermic acid(3),以及11种已知化合物(4-14)。通过光谱和质谱分析确定了三种新化合物的结构。评价了化合物1、4-6、13和14对RAW 264.7细胞中LPS刺激的亚硝酸盐产物中一氧化氮生成的抑制作用,IC50值分别为6.12、16.43、18.98、9.30、9.30和14.90μg/ mL。查看全文

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