CONSERVED LINKAGE WITHIN A 4-cM REGION OF MOUSE CHROMOSOME 9 AND HUMAN CHROMOSOME 11

摘要

A six-point cross was carried out to determine the gene order and distances among loci on mouse chromosome 9 . Our results are consistent with the following arrangement: centromere - Lap-1 - (1.2 ± 0.8) - Es-17 - (3.0 ± 1.0) - Ups - (1.3 ± 0.7) - Alp-1 - (23.1 ± 3.4) - Mod-1 - (10.9 ± 2.6) - Acy-1 . This study provides the first estimate of the distances between Es-17, Ups and Alp-1 . Exceptions to the preferred association of alleles of Es-17 and Ups have been found in three feral populations and one inbred strain. Evidence is presented for the homology of this chromosome region with the ESA4 - UPS - APO-AI region on the long arm of human chromosome 11 .