Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia

Irena Arandjelovi?; Matthias Merker; Elvira Richter; Thomas A. Kohl; Branislava Savi?; Ivan Soldatovi?; Thierry Wirth; Dragana Vukovi?; Stefan Niemann

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Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia

机译：塞尔维亚医院环境中多药耐药性结核的纵向爆发

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A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008–2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition of additional resistance and bacterial fitness–related mutations over 2 decades.

机译：一项对塞尔维亚多药耐药结核分枝杆菌复杂菌株的基于人群的分子流行病学回顾性研究（2008-2014年）显示，1990年左右开始在一家精神病医院爆发了TUR基因型菌株。药物缺乏，感染控制不佳和精神分裂症可能会助长收购超过20年的额外耐药性和细菌适应性相关突变。

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《Emerging Infectious Diseases》 |2019年第3期|共4页
作者
Irena Arandjelovi?; Matthias Merker; Elvira Richter; Thomas A. Kohl; Branislava Savi?; Ivan Soldatovi?; Thierry Wirth; Dragana Vukovi?; Stefan Niemann;
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中图分类传染病;
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antimicrobial resistancebacteriaMDR TBmultidrug-resistantoutbreakSerbiatransmissiontuberculosistuberculosis and other mycobacteriawhole-genome sequencing;

机译：抗菌素耐药菌耐多药结核病多重耐药性暴发塞尔维亚传播结核病结核分枝杆菌和其他分枝杆菌全基因组测序;

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专利

1. Use and efficacy of tuberculosis infection control practices at hospitals with previous outbreaks of multidrug-resistant tuberculosis. [J] . Tokars JI, McKinley GF, Otten J, Infection control and hospital epidemiology . 2001,第7期

机译：在先前爆发多药耐药结核病的医院中，结核病感染控制措施的使用和功效。
2. Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-Resistant Mycobacterium tuberculosis M and Ra Strains [J] . Laura Geffner, Noemí Yokobori, Juan Basile, Infection and immunity . 2009,第11期

机译：耐多药结核分枝杆菌M和Ra株爆发时，耐多药结核病患者的Th1反应受损，调节性T细胞水平增强
3. Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-Resistant Mycobacterium tuberculosis M and Ra Strains [J] . Laura Geffner, Noemí Yokobori, Juan Basile, Infection and immunity . 2009,第11期

机译：耐多药结核分枝杆菌M和Ra株爆发时，耐多药结核病患者的Th1反应受损，调节性T细胞水平增强
4. The Complex Treatment with Mellozan Immunomodulator of Patients with Multidrug-Resistant Tuberculosis [C] . Sain D., Cula E., Nepoliuc L., World Asthma and COPD Forum . 2010

机译：多药抗性结核病患者Mellozan免疫调节器的复杂处理
5. Risk Factors for Tuberculosis and Multidrug-Resistant Tuberculosis Complications among Foreign-Born Persons in Houston, Texas. [D] . Isaboke, James N. 2016

机译：得克萨斯州休斯顿的外国出生人士中结核病和耐多药结核病并发症的危险因素。
6. Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting Serbia [O] . Irena Arandjelović, Matthias Merker, Elvira Richter, 2019

机译：塞尔维亚医院环境中多药耐药性结核的纵向爆发
7. Patients with Multidrug-Resistant Tuberculosis Display Impaired Th1 Responses and Enhanced Regulatory T-Cell Levels in Response to an Outbreak of Multidrug-Resistant Mycobacterium tuberculosis M and Ra Strains▿ [O] . Geffner, Laura, Yokobori, Noemí, Basile, Juan, 2009

机译：耐多药结核分枝杆菌M和Ra菌株爆发时，耐多药结核病患者的Th1反应受损，调节性T细胞水平增强

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia

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