Parvoviruses in Blood Donors and Transplant Patients, Italy

摘要

To the Editor: Parvoviruses (PARV) 4 and 5 are 2 genotypes of a novel human parvovirus, with 92% nucleotide identity, identifi ed in the plasma sample of a patient screened for acute HIV infection and in samples of manufactured plasma pools (1,2). Recently, PARV4 and PARV5 were identifi ed in blood samples from 3 of 26 cadavers from the United Kingdom, all of whom were positive for hepatitis C virus RNA and had a history of in-travenous drug use (3). PARV4/5 were also found in bone marrow (BM) and lymphoid tissues from 17 of 24 HIV-positive cadavers from Scotland (4) and in BM aspirates from 16 of 35 Ital-ian patients with AIDS (5). Little or no information is available about the epi-demiology and clinical correlates of infection with these novel viruses. To provide insights into their pathogenic potential in vivo, we assessed the fre-quency of PARV4/5 viremia in healthy patients, transplant patients, and those with suspected viral disease