Inter-eye Differences in Bilaterally Myopic Patients with Unilateral Normal-tension Glaucoma

摘要

Purpose: To evaluate the inter-eye differences in bilaterally myopic patients with unilateral normal-tension glaucoma (NTG). Methods: Bilaterally myopic patients with unilateral NTG were consecutively enrolled. Both eyes of each individual were compared with regard to intraocular pressure (IOP), spectral-domain optical coherence tomography parameters (circumpapillary retinal nerve fiber layer [cpRNFL] thickness, disc area, and ?2-zone parapapillary atrophy [PPA] area), refractive error, and axial length (AL). Results: Thirty-six bilaterally myopic patients with unilateral NTG were included. The untreated mean and highest IOP of NTG eyes were not significantly different from those of contralateral non-glaucomatous eyes (p = 0.837; p = 0.908, respectively). Average, superior and inferior quadrants of cpRNFL thickness in NTG eyes were thinner than those obtained for contralateral non-glaucomatous eyes (p = 0.000; p = 0.000; p = 0.000, respectively). Compared with contralateral non-glaucomatous eyes, NTG eyes exhibited reduced disc areas (1.91 ?± 0.54 vs. 2.02 ?± 0.50 mm2, p = 0.040), but the ?2-zone PPA areas in NTG eyes were larger (1.40 ?± 0.75 vs. 0.98 ?± 0.56 mm2, p = 0.000). NTG eyes had more myopic refractive error and longer AL than contralateral non-glaucomatous eyes (-5.73 ?± 1.87 vs. -4.92 ?± 2.01 D, p = 0.000; 26.42 ?± 1.04 vs. 26.08 ?± 1.11 mm, p = 0.000). Conclusions: In myopic individuals, NTG eyes had longer AL, more myopic refractive error and larger ?2-zone PPA areas than contralateral non-glaucomatous eyes. Inter-eye AL differences may contribute to the development of NTG in myopes.