Prevalence and Systemic Relevant Factors of Polypoidal Choroidal Vasculopathy in a General Japanese Population: The Hisayama Study

摘要

Purpose: : To examine the prevalence of polypoidal choroidal vasculopathy (PCV) and its systemic relevant factors in a general Japanese population aged 50 years or older. Methods: : In 2007, 2,667 Hisayama residents consented to participate in the study. Each participant underwent a comprehensive examination that included ophthalmic testing. The presence of PCV was determined by color fundus photographs, fluorescein angiography findings, and indocyanine green angiography findings. Logistic regression analysis was performed to determine the systemic relevant factors of PCV. Results: : Of the 2,667 subjects examined, the prevalence of PCV was 0.3%. The frequency of PCV was 27.3% among subjects with any age-related macular degeneration (AMD) including wet AMD, dry AMD, and PCV. Men were found to have a significantly higher prevalence of PCV than women (age-adjusted odds ratio [OR], 5.56; 95% confidence interval [CI], 1.17 to 26.3). After adjustment for age and sex, it was found that smoking habit was significantly associated with PCV (age and sex-adjusted OR, 4.44; 95% CI, 1.15 to 17.2). Conclusions: : Our findings suggest that the prevalence of PCV is higher in the Japanese than in Caucasians and similar to that of other Asians, and that smoking habit is a significant relevant factor of PCV in the Japanese.