Antibodies to plasmodium falciparum glutamic acid rich protein (PfGARP) inhibit parasite growth by arresting trophozoite development

摘要

Background: Malaria affects almost one-half of the world's population and causes more than 600,000 deaths annually. Young children in malaria endemic areas of Africa have the highest mortality rate because of their immature immune systems. In previous vaccine discovery efforts, we developed a differential screening method using plasma from children who were resistant or susceptible to falciparum malaria. Using this approach, we discovered PfSEA-1. Antibodies to PfSEA-1 predict resistance to severe disease in two yr old children, block schizont egress from infected RBC in vitro, and vaccination with rPbSEA-1A protects mice from P.