Relatively speaking, antimalarial drug discovery from phenotypic whole cell screening has been far more successful than target-based approaches in delivering selective antimalarial drug candidates for a variety of reasons. It has recently been demonstrated that chances of discovering cell permeable and active antimalarials with potentially novel modes of action are significantly maximized through phenotypic screening. Compounds may easily be dismissed from target-based screening approaches if the desirable activity against the target is not achieved.
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