Simulated post-exposure rabies vaccination: comments on article by Madhusudana et al.

摘要

The paper by S.N. Madhusudana et al.1 cannot be left without comments. Potency (the amount of antigen) in vaccine is one of the determinants of immunogenicity and efficacy. In the case of tissue culture rabies vaccines, this was recognized in the early 1980s when 2.5?IU/dose was declared the minimum acceptable level.2 This number was based on administration of the vaccine as one full dose intramuscularly. Reduced dose intradermal vaccine schedules were not introduced until later that decade.3,4 We performed a study using Japanese-made purified chick embryo vaccine (PCEC) with a potency of 3.6?IU/ampoule, supplied with 1.0?mL diluent.