Management of antiretroviral therapy failure in resource limited settings

摘要

HAART in resource-limited settings(80% of 34 million HIV-infected patients were living inlow- and middle-income countries, andat least 6.6 million were on HAART. Most patients in RLS are treated with NNRTI-based regimen, nevirapine+3TC+AZT or d4T in particular. Several studies either in Africa or Asia have shown the viral success rate (plasma VL<50-400 c/ml) was varied from 70%-90% (ITT analyses). The two most common causes of treatment failure are non-adherence and drug-related toxicity.