The role of antimicrobial stewardship in curbing Carbapenem resistance

摘要

Carbapenem resistance in Acinetobacter baumannii and Enterobacteriaceae ranks as one of the most serious and challenging public health problem worldwide. Antibiotic treatment option is extremely limited and antibiotic development pipeline for gram-negative bacteria is unpromising. While KPC beta-lactamases are currently reported in North America and Europe, and limited countries in the Far East, OXA carbapenemases in A. baumannii and New Delhi metallo-beta-lactamase (NDM-1) in Enterobacteriaceae have disseminated globally.