Survey for carbapenemase-producing Klebsiella pneumoniae isolated from clinical specimens in Thai hospitals

摘要

Background: Carbapenems, broad spectrum β-lactam antibiotics are the most effective therapy for various serious infections included those caused by Enterobacteriaceae- producing extended spectrum β-lactamases (ESBLs). The rapid spread worldwide of carbapenem resistantKlebsiella pneumoniaeby producing enzymes K. pneumoniae carbapenemases (KPCs) limited the effectiveness of carbapenems in the treatment of multidrug-resistant infections. Adequate detection of carbapenemase-producingEnterobacteriaceaein routine diagnostic laboratory is essential for clinical management.