Association of polymorphism within promoter of the interferon-gamma receptor gene and HBV chronicity among Iranian patients

摘要

Background: polymorphism within regulatory regions of immune response genes can affect the level of gene expression. Gamma interferon (INF-g) is a cytokine that plays an important role in immune response to infection of hepatitis B virus (HBV). The aim of this study is to explore the association between the two single nucleotide polymorphisms (SNPs) within promoter (at positions -611G/A,-56T/C) of the gamma interferon receptor1 gene (INFGR1) and susceptibility to chronic HBV infection.