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Disseminated cutaneous sporotrichosis in an immunocompetent individual

机译:具有免疫功能的个体中的播散性皮肤孢子体病

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Sporotrichosis is a subacute or chronic fungal infection caused by the ubiquitous fungus Sporothrix schenckii. Disseminated cutaneous sporotrichosis is an uncommon entity and is usually present in the immunosuppressed. Here, a case of disseminated cutaneous sporotrichosis in an immunocompetent patient is reported. This 70-year-old healthy woman presented with multiple painful ulcerated nodules on her face and upper and lower extremities of 6-month duration, associated with low-grade fever, night sweats, loss of appetite, and loss of weight. Histopathological examination of the skin biopsy revealed epidermal hyperplasia and granulomatous inflammation in the dermis, with budding yeast. Fungal culture identified S. schenckii. She had total resolution of the lesions after 2 weeks of intravenous amphotericin B and 8 months of oral itraconazole. All investigations for underlying immunosuppression and internal organ involvement were negative. This case reiterates that disseminated cutaneous sporotrichosis, although common in the immunosuppressed, can also be seen in immunocompetent patients.
机译:孢子丝菌病是由无处不在的真菌Schenothrix schenckii引起的亚急性或慢性真菌感染。弥漫性皮肤孢子囊病是罕见的实体,通常存在于免疫抑制中。在此,报道了在具有免疫能力的患者中散布的皮肤孢子囊病的情况。这位70岁的健康妇女的面部以及上肢和下肢六个月持续出现多处溃疡性结节,伴有低烧,盗汗,食欲不振和体重减轻。皮肤活检的组织病理学检查发现真皮中有表皮增生和芽肉芽肿性炎症,并伴有发芽酵母。真菌培养鉴定为S. schenckii。静脉注射两性霉素B 2周和口服伊曲康唑8个月后,她已完全治愈了病变。所有有关潜在免疫抑制和内部器官受累的调查均为阴性。该病例重申,尽管在免疫抑制中很常见,但也可以在免疫功能正常的患者中看到弥漫性皮肤孢子囊病。

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