Cryptococcal immune reconstitution syndrome in HIV-negative patients

摘要

I read with interest the case report by Narayanan et al.1 on cryptococcal immune reconstitution inflammatory syndrome (IRIS) during steroid withdrawal. Corticosteroids are known to depress the host response by suppression of the inflammatory response. Treatment with corticosteroids has been shown to be the common underlying condition predisposing to cryptococcosis in non-HIV-infected patients.2–5 We also had a patient at our institution who, after treatment with prednisone for nephrotic syndrome for 2 years, developed cryptococcal meningitis.