Expression of matrix metalloproteinases and tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis

摘要

Background: The mortality rate in meningitis is relative high and the survivors may suffer from long-term severe neurological sequelae. Infectious meningitis is associated with an imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMP (TIMPs). The aim of the study was to determine the levels of matrix metalloproteinase-2, 9 (MMP-2, 9) and tissue inhibitors of matrix metalloproteinase1, 2, 4 (TIMP-1, 2, 4) profiles of patients enrolled in a clinical cohort of infectious meningitis.