Ixodes persulcatus tick salivary gland extract (SGE) inhibits IL-4 and IFN-/ secretion and CD69 expression by mitogen-stimulated murine splenocytes

摘要

Background: The tick Ixodes persulcatus are the main vector of Lyme disease and viral encephalitis in Europe and Asia. Immunosuppressive agents in tick saliva aid successful blood meal acquisition and appear critical to the transmission and establishment of pathogens, both viral and bacterial. Our present work was undertaken to investigate modulation of IL-4, IFN?/ production and CD69 expression of murine splenocytes byI. persulcatus SGE, derived from unfed and partially fed (3 days) I. persulcatus.