Analysis of Bordetella pertussis Agglutinin Titer in the Patients with Adolescent/Adult Pertussis

摘要

Background:Bordetella pertussis is a gram-negative bacterium that infects a respiratory tract and causes pertussis. B. pertussis contains agglutinogen. Major agglutinogen, Agg2 and Agg3 is derived from Tohama strain (vaccine strain) and Yamaguchi strain (epidemic strain) respectively. Pertussis is diagnosed by nasopharyngeal culture, PCR and serologic tests for B. pertussis. As a serologic test, the agglutinin titers against Tohama and Yamaguchi strain are measured widely in Japan. The criterion for infants pertussis established by the National Institute of Infectious Diseases was employed: a ≥1:40 agglutinin titer of Yamaguchi strain has a diagnostic value.