Immunogenicity of Novel Consensus-Based DNA Vaccines Against Chikungunya Virus

摘要

CHIKV is an emerging arbovirus and is an important human pathogen that causes a syndrome characterized by fever, headache, rash, nausea, vomiting, myalgia, arthralgia and occasionally neurological manifestations such as acute limb weakness. It is also associated with a fatal haemorrhagic condition. CHIKV is geographically distributed from Africa through Southeast Asia and South America, and its transmission to humans is mainly through Aedes species mosquitoes. The frequency of recent epidemics in the Indian Ocean islands suggests that something else was carrying the virus, as Aedes aegypti are not found there.