Co-existent pneumococcal and tubercular mixed meningitis in heterozygous sickle cell disease: a case report

摘要

Sickle cell disease is an inherited disorder that presents with a diverse group of clinical syndromes. Dr James Herrick first reported the disease in the year 1910.1 Ingram identified the substitution of valine for glutamic acid as the sixth amino acid of the beta globin chain. Since then a multitude of amino acid substitutions occurring at different regions of the beta globin chain have been reported, leading to a spectrum of clinical presentations. We report on a patient with heterozygous sickle cell disease (HbSD) presenting with mixed meningitis due to Streptococcus pneumoniae and Mycobacterium tuberculosis.