Mathematical Model for Hemodynamicand Hormonal Effects of Human Ghrelin in Healthy Volunteers

摘要

Hemodynamicand hormonal effects of human ghrelin in healthy volunteers.To investigate hemodynamic and hormonaleffects of ghrelin, a novel growth hormone (GH)-releasing peptide, we gave six healthy men an intravenousbolus of human ghrelin or placebo and vice versa1–2 wk apart in a randomized fashion. Ghrelin elicited amarked increase in circulating GH . The elevation ofGH lasted longer than 60 min after the bolus injection.Injection of ghrelin significantly decreased mean arterialpressure without a significant changein heart rate .In summary, human ghrelin elicited a potent, longlastingGH release and had beneficial hemodynamic effectsvia reducing cardiac afterload and increasing cardiac outputwithout an increase in heart rate. Thus, the purpose of thisstudy was to investigate hemodynamic and hormonaleffects of intravenous ghrelin in healthy volunteers. This paper discussed the constant stress level of healthy volunteers with times to damage of stress effect andrecoveries