A lipopolysaccharide obtained in a dialyzed phenol extract from the rickettsia Coxiella burneti produced the following effects in guinea pigs after intraperitoneal injection: hyperthermia, loss of body weight, increased liver weight and concomitant lipid infiltration, elevated levels of hepatic and plasma cortisol, increased incorporation of [3H]orotic acid into hepatic 28S and 18S ribosomal ribonucleic acid, increased incorporation of 14C-labeled amino acids into liver and plasma protein, and leukocytosis. Most of these events also occur during infection of guinea pigs with C. burneti, and a causal relationship between the rickettsial lipopolysaccharide and the biochemical changes that occur during Q fever is suggested.
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机译：立克次氏体Coxiella burneti的透析酚提取物中获得的脂多糖在腹腔内注射后对豚鼠产生以下作用：体温过高，体重减轻，肝脏重量增加和伴随的脂质渗透，肝水平升高和血浆皮质醇，增加[ 3 H]乳清酸在肝28 S 和18 S 核糖体核糖核酸中的掺入， 14 C标记的氨基酸进入肝脏和血浆蛋白，并引起白细胞增多。这些事件大多数也发生在豚鼠感染 C期间。提示伯尼氏酵母菌，并指出了立克次体脂多糖与Q发热期间发生的生化变化之间的因果关系。
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