Plasmid-Borne Type E Neurotoxin Gene Clusters in Clostridium botulinum Strains

Zhen Zhang; Hannamari Hintsa; Ying Chen; Hannu Korkeala; Miia Lindstr?m

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Plasmid-Borne Type E Neurotoxin Gene Clusters in Clostridium botulinum Strains

机译：肉毒梭菌菌株中的质粒-B型E型神经毒素基因簇

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A collection of 36 Clostridium botulinum type E strains was examined by pulsed-field gel electrophoresis (PFGE) and Southern hybridization with probes targeted to botE and orfX1 in the neurotoxin gene cluster. Three strains were found to contain neurotoxin subtype E1 gene clusters in large plasmids of about 146 kb in size.

机译：通过脉冲场凝胶电泳（PFGE）和Southern杂交检测了36种E型肉毒梭菌菌株，并用神经毒素基因簇中针对botE和orfX1的探针进行了杂交。发现三个菌株在大小约为146 kb的大型质粒中含有神经毒素亚型E1基因簇。

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《Applied and Environmental Microbiology》 |2013年第12期|共4页
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Zhen Zhang; Hannamari Hintsa; Ying Chen; Hannu Korkeala; Miia Lindstr?m;
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1. Plasmid-Borne Type E Neurotoxin Gene Clusters in Clostridium botulinum Strains [J] . Zhen Zhang, Hannamari Hintsa, Ying Chen, Applied Microbiology . 2013,第12期

机译：肉毒梭菌菌株中的质粒-B型E型神经毒素基因簇
2. Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts [J] . Andrew T. Carter, John W. Austin, Kelly A. Weedmark, Genome Biology and Evolution . 2016,第3期

机译：染色体梭菌肉毒杆菌型E型神经毒素基因集群的演变：由其稀有质粒传播的同行提供的证据
3. Sequencing the Botulinum Neurotoxin Gene and Related Genes in Clostridium botulinum Type E Strains Reveals orfx3 and a Novel Type E Neurotoxin Subtype [J] . Ying Chen, Hannu Korkeala, Johannes Aarnikunnas, Journal of bacteriology . 2007,第23期

机译：肉毒梭菌E型菌株肉毒杆菌神经毒素基因及相关基因的测序揭示了orfx3和新型E型神经毒素亚型
4. Identification of Disulfide Bridges in Clostridium botulinum Neurotoxin by Mass Spectrometry [C] . Hua Huang, Nemone Muster, Tai Huynh, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：质谱法鉴定梭菌肉毒杆菌神经毒素的二硫桥
5. Analysis of type A botulinum neurotoxin expression in Clostridium botulinum. [D] . Dineen, Sean S. 2003

机译：分析肉毒梭菌中A型肉毒杆菌神经毒素的表达。
6. Plasmid-Borne Type E Neurotoxin Gene Clusters in Clostridium botulinum Strains [O] . Zhen Zhang, Hannamari Hintsa, Ying Chen, 1993

机译：肉毒梭菌菌株中的质粒-B型E型神经毒素基因簇
7. Evidence that Plasmid-Borne Botulinum Neurotoxin Type B Genes Are Widespread among Clostridium botulinum Serotype B Strains [O] . Franciosa, Giovanna, Maugliani, Antonella, Scalfaro, Concetta, 2009

机译：在肉毒梭菌血清B型菌株中广泛传播质粒B型肉毒杆菌神经毒素B基因的证据。
8. Recombination and Insertion Events Involving the Botulinum Neurotoxin Complex Genes in Clostridium botulinum Types A, B, E and F and Clostridium butyricum Type E Strains [R] . Hill, K. K., Xie, G., Foley, B. T., 2009

机译：a型，B型，E型和a型梭菌属肉毒杆菌和E型梭菌属肉毒杆菌神经毒素复合基因的重组和插入事件

Plasmid-Borne Type E Neurotoxin Gene Clusters in Clostridium botulinum Strains

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