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首页> 外文期刊>Acta Crystallographica Section E: Crystallographic Communications >3-Amino-N-benzyl-6-(4-fluoro-phen-yl)thieno[2,3-b]pyridine-2-carboxamide
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3-Amino-N-benzyl-6-(4-fluoro-phen-yl)thieno[2,3-b]pyridine-2-carboxamide

机译:3-氨基-N-苄基-6-(4-氟-苯甲酰基)噻吩并[2,3-b]吡啶-2-羧酰胺

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摘要

In the title compound, C21H16FN3OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57?(12) and 83.87?(5)° with the fluoro-phenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, mol-ecules are linked by weak N—H?N anf N—H?O hydrogen bonds and π–π stacking inter-actions involving fluoro-phenyl rings of adjacent mol-ecules, with a centroid–centroid distance of 3.648?(10)??. In addition, intra-molecular N—H?S and N—H?O hydrogen bonds contribute to the stability of the mol-ecular conformation.
机译:在标题化合物C21H16FN3OS中,噻吩并[2,3-b]吡啶体系与氟苯基环在6位和苯基环形成10.57°(12)和83.87°(5)°的二面角。分别是苄基。在晶体中,mol-ecule通过弱的NH-Nf N-H-O氢键和涉及相邻mol-ecule的氟苯基环的π-π堆积相互作用连接,质心-质心距离为3.648?(10)??。另外,分子内NH 3 S和NH 3 O氢键有助于分子构象的稳定性。

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