The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine

摘要

Background:Secreted protein acidic and rich in cysteine (SPARC), a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix and is capable of altering the growth of various cancers. We therefore sought to determine the effect of SPARC expression on medulloblastoma tumour growth and angiogenesis.