富含半胱氨酸的酸性分泌蛋白在肺癌和肺纤维化中的研究进展

摘要

富含半胱氨酸的酸性分泌蛋白(SPARC)可调控细胞基本功能如黏附、增殖和分化,同时也调控生长因子以及细胞外基质(ECM)降解和转化必需的基质金属蛋白酶(MMPs)的表达和活性.在非小细胞肺癌(NSCLC)和特发性肺纤维化(IPF)中,SPARC通过促进微血管改造和ECM中蛋白过度沉积发挥作用.而SPARC在慢性呼吸道疾病如哮喘和慢性阻塞性肺疾病(COPD)中的作用一直不被重视.为此,本文综述了SPARC在NSCLC和IPF中的作用研究,并提出未来应研究SPARC在哮喘和COPD中的作用.%Secreted protein acidic and rich in cysteine(SPARC)governs fundamental cellular functions such as cell adhesion, proliferation and differentiation,and also regulates the expression and activities of numerous growth factors and matrix metalloproteinases (MMPs)which are essential for degradation and turnover of extracellular matrix(ECM).In the lung,SPARC drives pathological responses in non-small cell lung cancer(NSCLC)and idiopathic pulmonary fibrosis(IPF)by promoting microvascular remodeling and excessive deposition of ECM proteins.However, the role of SPARC in chronic airway conditions, such as asthma and chronic obstructive pulmonary disease(COPD),has far been overlooked.This article reviewed current progress of its role in NSCLC and IPF, and highlighted its effect in chronic airway diseases such as asthma and COPD.