5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

K Bracht; A M Nicholls; Y Liu; W F Bodmer

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5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

机译：大量大肠癌细胞系中的5-氟尿嘧啶反应与错配修复缺陷相关

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Background:Colorectal cancer is (CRC) one of the commonest cancers and its therapy is still based on few drugs. Currently, no biological criteria are used to choose the most effective of the established drugs for treatment.

机译：背景：大肠癌是（CRC）最常见的癌症之一，其治疗仍以几种药物为基础。当前，没有生物学标准用于选择最有效的既定治疗药物。

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《British Journal of Cancer 》 |2010年第3期| 共7页
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K Bracht; A M Nicholls; Y Liu; W F Bodmer;
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中图分类肿瘤学 ;
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1. DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status [J] . Birgitte L. Adamsen, Katherine L. Kravik, Paula M. De Angelis International journal of oncology . 2011 ,第3期

机译：三种错配修复和TP53状态不同的大肠癌细胞株对5-氟尿嘧啶的DNA损伤信号传递
2. MicroRNA-552 deficiency mediates 5-fluorouracil resistance by targeting SMAD2 signaling in DNA-mismatch-repair-deficient colorectal cancer [J] . Zhao Ping, Ma Yu-guang, Zhao Yang, Cancer chemotherapy and pharmacology. . 2019 ,第2期

机译：MicroRNA-552缺乏通过靶向SMAD2信号传导在DNA-Mismatch-Reation-缺陷性结直肠癌中介导5-氟尿嘧啶抗性
3. Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels [J] . Stadler Zsofia K., Battaglin Francesca, Middha Sumit, Journal of Clinical Oncology . 2016 ,第18期

机译：使用下一代测序组中的突变负荷可靠检测大肠癌的错配修复缺陷。
4. Mismatch repair competency predicts 5-fluorouracil effectiveness on patient survival [C] . J. M. CARETHERS, H. CHUNG, A. TAJIM Falk Symposium . 2007

机译：不匹配修复能力预测患者生存的5-氟尿嘧啶效果
5. Identification of Genomic Predictors of Response to the CDK4/6 Inhibitor Palbociclib using the UCLATORL Panel of Human Cancer Cell Lines [D] . Conklin, Dylan Francis 2013

机译：使用人类癌细胞系UCLATORL小组鉴定对CDK4 / 6抑制剂Palbociclib应答的基因组预测因子
6. 5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency [O] . K Bracht, A M Nicholls, Y Liu, 2010

机译：大量大肠癌细胞系中的5-氟尿嘧啶反应与错配修复缺陷相关
7. 5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency. [O] . Bracht, K, Nicholls, AM, Liu, Y, 2010

机译：一大批大肠癌细胞系中的5-氟尿嘧啶反应与错配修复缺陷有关。
8. Genetic Analysis of DNA Repair Deficiency in Novel Non-Tumor Adjacent and Tumor Cell Lines Suggests a New Paradigm of Breast Cancer Etiology [R] . Latimer, J. J. 2005

机译：新型非肿瘤相邻和肿瘤细胞系DNa修复缺陷的遗传分析表明乳腺癌病因学的新范式

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

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