An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

Z Zhang; Y Liu; T Song; Z Xue; X Shen; F Liang; Y Zhao; Z Li; H Sheng

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An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

机译：抗凋亡的Bcl-2家族蛋白指数预测白血病细胞对pan-Bcl-2抑制剂S1的反应

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Background:Bcl-2-like members have been found to be inherently overexpressed in many types of haematologic malignancies. The small-molecule S1 is a BH3 mimetic and a triple inhibitor of Bcl-2, Mcl-1 and Bcl-XL.

机译：背景：已发现在许多类型的血液系统恶性肿瘤中，Bcl-2样成员固有地过表达。小分子S1是BH3模拟物，是Bcl-2，Mcl-1和Bcl-XL的三重抑制剂。

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《British Journal of Cancer》 |2013年第9期|共9页
作者
Z Zhang; Y Liu; T Song; Z Xue; X Shen; F Liang; Y Zhao; Z Li; H Sheng;
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中图分类肿瘤学;
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1. Apogossypolone,a novel inhibitor of antiapoptotic Bcl-2 family proteins,induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro [J] . Xian-Qing Zhang, Shi-Jie Mu, Dao-Cheng Wu, 亚洲男性学杂志（英文版） . 2010,第005期

机译：Apogossypolone，一种抗凋亡的Bcl-2家族蛋白的新型抑制剂，在体外诱导PC-3和LNCaP前列腺癌细胞的自噬。
2. ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. [J] . Sun J, Li ZM, Hu ZY, Anti-cancer drugs . 2008,第10期

机译：ApoG2在人淋巴瘤U937细胞中抑制抗凋亡的Bcl-2家族蛋白并诱导线粒体依赖性凋亡。
3. Synthesis and biological evaluation of apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins [J] . Wei J., Kitada S., Stebbins J.L., Journal of Medicinal Chemistry . 2010,第22期

机译：载脂孢子酮衍生物作为抗凋亡B细胞淋巴瘤/白血病2（Bcl-2）家族蛋白的泛活性抑制剂的合成和生物学评估
4. Ultrafiltration Tandem Mass Spectrometry Based Screening Assay for the Discovery of Bcl-2 Family Antiapoptotic Protein Inhibitors. [C] . Suma Ramagiri, Fei Ma, Eldon Geisert, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：超滤串联质谱基于Bcl-2家族抗凋亡蛋白抑制剂发现的筛选试验。
5. Investigations into foldameric inhibitors of protein-protein interactions: Studies of the Bcl-2 family of proteins and vascular endothelial growth factor. [D] . Kaufman, Kimberly Joy. 2010

机译：蛋白质-蛋白质相互作用的折叠抑制剂研究：蛋白质Bcl-2家族和血管内皮生长因子的研究。
6. An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1 [O] . Z Zhang, Y Liu, T Song, 2013

机译：抗凋亡的Bcl-2家族蛋白指数预测白血病细胞对pan-Bcl-2抑制剂S1的反应
7. An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1 [O] . Z Zhang, Y Liu, T Song, 2013

机译：抗曝气Bcl-2家族蛋白指数预测睫毛细胞对Pan-Bcl-2抑制剂S1的响应

An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

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