Cyanosilylation of Carbonyl Compounds Catalyzed by Potassium L-Aspartate

摘要

Potassium L-aspartate has been used as a catalyst for the cyanosilylation of carbonyl compounds producing corresponding cyanohydrin trimethylsilyl ethers in excellent yield of up to 98%. Although the catalyst is chiral, the enantioselectivities observed are generally poor except for one case, メ-naphthaldehyde, 89% ee.